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Home > Policy > White Paper, Notice, Announcement > White Paper > Annual Report on the Promotion of Science and Technology 2000 > Part1 Chapter2 Section1 4 | ![]() |
"BCG," an immunization to prevent tuberculosis,
was developed and this resulted in a reduction of the number of deaths caused
by tuberculosis, a disease which was previously feared as incurable ( Fig.
9 ).
Many other important facts were discovered in the 20th century,
including the discovery of "syphilis Spirochaeta," the bacteria that
causes syphilis, and the development of "Salvarsan" as a curative medicine
for the disease, the extraction of "insulin" as a drug effective in
treating diabetes, the extraction of "penicillin," a specific medicine
against bacterial infections, and the discovery of "interferons," which
are virus suppressors.
The popularization of X-ray imaging which utilizes the differences
in X-ray absorption of the various tissues of human and foreign bodies to create
images, and the invention of electrocardiographs which measure and record minute
changes in current generated cyclically by the heart have played important roles
in diagnosis and treatment.
In addition, computer tomography scans (CT scans), magnetic
resonance imaging (MRI), ultrasound diagnosis and other image diagnosis technology
and cancer treatment technology using gamma rays have been developed one after
another, and have already been implemented.
Research is also currently being carried out into Boron Neutron
Complementation Treatment (BNCT), cancer diagnosis and treatment using proton
rays, and cancer treatment using radiation such as Heavy Ion Medical Accelerator
in Chiba (HIMAC).
The discovery of the ABO blood group, in addition to the knowledge
from immunology and genetic science, enabled safe blood transfusions.
In 1954 the first successful kidney transplant occurred, and
the first successful heart transplant in 1967. Thus, in the 20th century organ
transplant has advanced with the understanding of the immune system. In recent
years, in the Western countries, more than 3,000 heart transplants are carried
out from brain-dead patients each year, in this way organ transplants from brain-dead
donors succeed more and more, and these transplants are taking root as part of
everyday medicine.
In 1968 a heart transplant operation was carried out in Japan,
but after the death of the patient involved, it brought about problems such as
the definition of brain-death and the ethics of doctors, and until "the
Law Concerning the Transplant of Organs" came into effect in 1997, organ
transplants were not carried out from brain-dead patients.
With the discovery of the double-helix structure of DNA in
1953, DNA is regarded as a centerpiece of life phenomena. These breakthroughs
in biology have progressed at a rapid pace.
A genetic recombination experiment succeeded in 1973. Currently
genetic recombination technology is being applied to the medical field through
the development of new pharmaceuticals and treatment methods, to the agricultural
field through the development of crops that are resistant to disease, and to
other varieties of fields.
Meanwhile, there are increasing calls for verification of
the safety of genetically modified crops and genetically modified foods, so the
creation and examination of an internationally appropriate framework of regulations.
Thanks to "the Human Genome Project" that is currently
being advanced by international cooperation, all basic arrays of DNA have been
unscrambled, and it is expected that the function of genes will be come clear.
By these advances it is expected that pharmaceuticals will be developed to treat
cancer and Alzheimer's disease, and that dramatic forward steps will take place
in diagnosis and treatment. Attention is also focussed on the fact that customized
medical care matched to the individual health.
With the birth of cloned sheep "Dolly" in 1997 as
a turning point, interest in cloning technology has increased in all over the
world.
The advances in genetic recombination technology and cloning
technology have lead to expectations for advances in technology in the agricultural
field. They will also enable the production of human growth hormone, and the
production of animals for organ transplants, and it is quite conceivable that
the immeasurable use of the technology in these fields will affect society in
the 21st century.
In relation to organ transplants, in Japan there has been
long-standing debate about whether brain-dead patients are dead or not. Currently,
based on the experience of organ transplants in accordance with "the Law
Concerning Transplant of Organs," debate is taking place about problems
such as the disclosure of information about the implementation of fair and accurate
brain-dead assessments, and the protection of private information about both
organ donors and recipients.
The application of cloning techniques to humans is predicted
to bring about a great deal of concern in the world from the perspective of ensuring
the dignity of human beings. In addition, research that uses human embryos, the
start of human life, brings world-wide debate, encompassing the development of
a framework of strict regulations.
With the unscrambling of the functions of genes which is expected
in the future, there are fears that a new type of discrimination will occur by
using the genetic makeup of the individual. Appropriate review is required concerning
the prevention of different types of discrimination in society caused by differences
in genetical makeup, and the protection of private information concerning genes.
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